BIRC5 (baculoviral IAP repeat containing 5)
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چکیده
منابع مشابه
BIRC 2 ( baculoviral IAP repeat - containing 2 )
Protein Description 618 amino acids. The protein contains three motifs, i.e., BIR (Baculoviral Inhibitor of Apoptosis Repeat) domain, RING (Really Interesting New Gene)-finger domain, and CARD (Caspase Recruitment Domain). Expression Wide, highly expressed in large intestine, lung, endometrium, bladder and salivary gland. Localisation Cytoplasmic and/or nucleus. Function Inhibition of apoptosis...
متن کاملAssociation Between a Polymorphism (rs2071214) in Baculoviral IAP Repeat Containing 5 Gene (BIRC5) and Ischemic Stroke in Korean Population
OBJECTIVE To investigate whether baculoviral inhibitor of apoptosis (IAP) repeat containing 5 gene (BIRC5) polymorphisms are associated with the development and clinical phenotypes of ischemic stroke in Korea population. METHODS We enrolled 121 ischemic stroke patients and 291 control subjects. Ischemic stroke patients were divided into subgroups according to the scores of National Institutes...
متن کاملBaculoviral IAP Repeat Containing 6 (BIRC6) Is a Predictor of Prognosis in Prostate Cancer
Background: Baculoviral IAP repeat containing 6 (BIRC6), a member of the inhibitors of apoptosis protein (IAP) family, has been reported to be correlated with oncogenesis. The aim of this study was to investigate the prognostic significance of BIRC6 in prostate cancer, as well as its effects on prostate cancer cell lines. Material/Methods: BIRC6 protein expression was investigated in 112 prosta...
متن کاملGenetic rearrangements of variable di-residue (RVD)-containing repeat arrays in a baculoviral TALEN system
Virus-derived gene transfer vectors have been successfully employed to express the transcription activator-like effector nucleases (TALENs) in mammalian cells. Since the DNA-binding domains of TALENs consist of the variable di-residue (RVD)-containing tandem repeat modules and virus genome with repeated sequences is susceptible to genetic recombination, we investigated several factors that migh...
متن کاملBIRC5 Genomic Copy Number Variation in Early-Onset Breast Cancer
Background: Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) gene is an inhibitor of apoptosis that expresses in human embryonic tissues but it is absent in most healthy adult tissues. The copy number of BIRC5 has been indicated to be highly increased in tumor tissues; however, its association with the age of onset in breast cancer is not well understood. Methods: Forty tumor tiss...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2019
ISSN: 1768-3262
DOI: 10.4267/2042/70468